Royal Air Force Typhoon FGR4s have conducted a mission with French aircraft in a coordinated attack targeting an underground arms cache in Syria operated by the IS group, per a report from the UK Ministry of Defence.
The location, pinpointed through reconnaissance, was thought to be containing munitions and bombs, the statement said, and was located in mountainous terrain just north of the historic site of Palmyra in central Syria.
"Our fighter planes used Paveway IV guided bombs to hit a several entry passages leading to the site... initial indications suggest the target was engaged successfully," officials stated.
There was no indication of any civilian impact in the strike on Saturday evening and each participating jet returned safely, the defence officials confirmed.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
Daesh - referred to as the so-called Islamic State - established militant control over large swathes of Syria and Iraq until 2019.
"This strike demonstrates the UK's leading role, and determination to operate in unison with our allies, to stamp out any re-emergence of IS and their violent and radical beliefs in the Middle East," the British Defence Secretary John Healey stated.
UK warplanes have performed patrols over Syrian airspace to "deter any efforts to regroup" of Islamic State following its routing at the climactic battle in Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of our armed forces who took part in this strike for their expertise and their valour," the Defence Secretary said. "Including them were a great many UK service members on duty over the holidays. This mission, to take out terrorist threats who pose a risk to our safety, highlights how British military are ready to step up, continuously, keeping Britain secure domestically and powerful internationally."
In December, the US military carried out what it termed a "massive strike" on Islamic State objectives in Syria, following an attack claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The U.N. reports IS still boasts between 5,000 and 7,000 fighters in both countries.